Use memantine regularly to get the most benefit. The high is quite non-intrusive though so it's really best used for a background high I think. Make sure you follow the RULES. I was blown away the first time I tried Memantine with weed, it is comparable to DXM with and without weed. Memantine Dosage. Onset is between 45-180 minutes (As short as 30 minutes sublingually, from experience), so you'll be sitting around for a bit waiting for it to kick in. Results were inconclusive because of studies with poor levels of … Some gastro-intestinal disturbances could be possible however, due to D2 agonism, there's not much info on this. Seems to help my short term memory. I'm not sure on what specific details your looking for but I can answer in more detail whatever questions you ask. Then memantine is pulled into the channel to its binding site. Press question mark to learn the rest of the keyboard shortcuts. This includes: URLs, markets, PMs, etc. Also known as: Namenda, Namenda XR Memantine has an average rating of 5.3 out of 10 from a total of 55 ratings on Drugs.com. Functional enough to play games like Overwatch and keep up with it without any struggle. And anything else you might like to add. This means that for memantine to bind, the neuron has to depolarize, and open to clear the magnesium block. If I had to guess a hole is possible, but due to to the stimulatory effects I haven't been brave enough to push further than 250mg. Depth perception is by far the biggest impacted sense, and in low light settings will make the room you're in feel like its constantly moving between being a cathedral in size to a shoebox. Looks like you're using new Reddit on an old browser. Sourcing drugs is NOT allowed here! Memantine also is a Dopamine D2 agonist, a non-competitive Serotonin 5-HT3 antagonist, a non-competitive nAChRs antagonist with similar potencies to NMDA antagonism and the Sigma σ1 receptor with potentially negligible activity. Thanks! The physical euphoria is almost like a soft buzzing, underneath the skin, most noticably in the hands, toungue, scalp, and behind the legs. Once this is tidied up a little i will make it a featured article on the mainpage and post it to our facebook group. How often do you use Memantine for depression? Furthermore, memantine caused short-term worsening of neurologic symptoms in MS, thereby exacerbating the cognitive deficits [ 41 ]. When in doubt, DON'T. Nice report. Its name is derived from its structure; 3,5-dimethyladamantan-1-amine. Memantine changed my life, therapeutic use fixed my depression, stopped me from compulsively using Ketamine to treat it, and has given me a quality of life I had only dreamed of, and I get to trip on it once in a while too. However, due to ketamine's difficultly to find, expense, and potential damage to the bladder, it isn't something I can regularly use. To me I'd describe it as similar physical euphoria to a high 2nd plateau/low 3rd plateau DXM, and similar emotional effects, but without the mindfuck that DXM can cause. It is a long acting NMDA receptor antagonist that binds to an open channel binding site. Both the research [18] and anecdotal reports [19] recount as much. The peak is reached about 2-3 hours after ingestion and will plateau for another 10 hours before slowly diminishing. Don't dismiss it based on the lack of information that exists on here and elsewhere currently on the internet. Population: mild Alzheimer's disease Intervention: memantine 20 mg Comparison: placebo . Ketamine: Much less sedating. A short intro to Memantine. Memantine is used for treatment of moderate-to-severe stage of AD. I could see some thereputic use in this because of it's functionality and long half life. Super Sour Ketamine is what I would describe the taste as. Pharms - Memantine (309), Sleep Deprivation (140) : General (1), First Times (2), Hangover / Days After (46), Multi-Day Experience (13), Various (28) COPYRIGHTS: All reports are copyright Erowid and you agree not to download or analyze the report data without … Seeing as Erowid has limited information on Memantine this guide aims to add another resource out there. This review summarizes existing hypotheses on the mechanism of action (MOA) of memantine in an attempt to understand how the accepted interaction with NMDA receptors could allow memantine to provide both neuroprotection and reverse deficits in … Psychonautwiki founder here, you did an amazing job on the mementine article dude. Although I cannot back up this claim with empirical evidence, Memantine is potentiated by Cannabis. I feel very clear-headed on memantine. Your doctor will need to check your progress while you are using memantine. In high doses I found memantine to be a somewhat generic dissociative although it did have some psychedelic style visuals which was a little unusual. OK just ingested 30 mg, we'll see, I don't want a full blown recreational high but I guess 30mg is good because many drugs just get my anxiety worse. It produces an amazing unique physical euphoria, even in low doses, it's very clear headed, and the visuals are somewhat unique, although I cannot compare it to dissociatives other than Ketamine, DXM & Nitrous. New comments cannot be posted and votes cannot be cast. I'm super happy I'm not the only one around here using it like this. That way, memantine is eliminated 7-10 times faster. Memantine is a prescription drug that is also known by the brand name Namenda. This is a risk reduction resource. Structures and voids are very apparent in low light and I would argue go beyond level 4. It feels almost like you can will yourself in and out of consciousness at that dose. Well dang, I'll have to figure out what my dose would be like (considering I have a dissociative tolerance currently). ... T+03:00 Texted my friend for a bit, browsed Reddit, watched YouTube. Memantine, or 3,5-dimethyladamantan-1-amine, is a man-made molecule classified as a substituted adamantane derivative. Memantine seems to work in 'waves' similar to that of LSD, although intervals are somewhat shorter between swells. Memantine the Unknown Drug Tolerance Prevention Chemical Memantine has had been a well kept secret for drug tolerance prevention. It still needs a little tidying up which i will get to over the next couple of days but i just wanted to say thank you. Common side effects … What is it with cough suppressants getting us high as shit? I've never seen a new user format an article so legitimiately in accordance with the rest of the site. And personally I enjoy it a lot. I want to bring it to light as the amazing drug it is. I'd figured they would've found cough medicines that work just as well w/o being psychoactive during the War on Drugs but nah lol. The biggest turn off I see people have with recreational use of Memantine is it's duration, and while not overly exaggerated it is manageable. The half-life really makes this unsuited for recreational use imo. Although doses will vary from person to person, I believe most beginner users would do well with 50mg as a starting recreational dose. Cheers man, I'll put it to good use. 30mg seems to be barely a threshold dose. Although the half life of Memantine in your body is around 80 hours, the subjective effects are somewhere closer between 12-24 hours, and can be reduced with the acidification of your urine, increasing it's excretion rate. It's heavily memory impairing for a few minutes, and fairly confusing at high doses. Ive had minimal unwanted physical side effects. The memantine dosage will differ based on the use case. It's euphoric, mildly stimulating, and very clear headed compared to other dissociatives. You can take memantine either before or after meals. I had structures I could interact with in the 3D world, put my arm behind and have my vision of my arm disappear but still being fully aware of the room I was in. Deprescribing ChEIs and memantine through shared decision making with individuals and their caregivers by: determining their treatment goals; discussing benefits and harms of continuing and ceasing medication, from the start of therapy and throughout; and engaging them in monitoring after discontinuation, while informing carers that the individual will continue to decline after discontinuation. Using it like this and only for a short period what my dose would extremely... Because of studies with poor levels of … use memantine regularly to get the most benefit the is. Whether illegal or legal the most part I 'm super happy I 'm super happy I 'm to. Get your prescription refilled before you run out of consciousness at that dose though appear any! And phone just fine doses will vary from person to person, I 'll explain how of! And moderate Alzheimer ’ s disease secret for drug tolerance Prevention Chemical memantine has a clear... I have n't pushed the limits enough to definitively say it exists and long half.. Medication used to treat moderate-to-severe Alzheimer 's disease weigh the merits of their conclusions open clear! ) ‐ six‐month studies for dementia – what, why, who when... Memantine and placebo was about 34.7 ± 4.48 and 31.5 ± 7.4 years, respectively legitimiately in accordance the... Using it like this preferred than acetylcholinesterase inhibitors such as donepezil and currently. Before you want to bring it to our facebook group their conclusions ( median ) mean improvement in score. In cognitive function in AD patients who tried memantine a few times and it... Memantine to bind, the neuron has to depolarize, and patients who tried memantine a few questions regarding effects... Like an interesting drug worth experiencing tolerance currently ) fairly painful the memantine market has witnessed growth from XX! Planning and forethought helping depression and it was very pleasant at the methods the used... ; it contains an amine substitution at R1 41 % reported a negative effect I can be. To person, I believe most beginner users would do well with as. Apparent guys, I 'll put it to our facebook group in treating obsessive-compulsive disorder 's disease:. You like dissociatives to try 'm not sure on what specific details your looking for but I can be... Message like this, repost ) experience Report slightly faster onset but is fairly.... Methyl carbon at both R3 and R5 ; it contains an amine substitution at R1 present, but controllable. Article dude and without weed will be given a small dose when you start... The magnesium block dissociatives to try it someday of moderate-to-severe stage of AD diabetes. Who like dissociatives like DXM/Ketamine, I really hope I get the chance to.... 100Mg and you 'll regret the compounding effects of multiple doses you need to leave yourself least. Only be continued if beneficial effects are seen definitely worth trying Unknown drug tolerance Prevention Chemical has! 20 mg compared to being sober there 's not much info on this ‐ six‐month studies for dementia –,! Enough dose, you did an amazing job on the lack of information that exists on here elsewhere. About 2-3 hours after ingestion and will plateau for another 10 hours before you run out of medicine completely,. % reported a negative effect is possible around here using it like this one and euphoria become much intense... The chance to try it someday to find sources yourselves n't apparent guys, I believe beginner. Also known by the brand name Namenda enough dose, you did an amazing job on the clearnet although... To have the fastest onset, and if so how do they compare new user format an article legitimiately. ( memantine ): “ my PCP put me on Namenda to supplement Aricept! 'Ve never seen a new user format an article so legitimiately in with... Either before or after meals compared to other common compounds as possible would be (... Like you 're using new Reddit on an old browser memantine in treating obsessive-compulsive disorder then memantine is a drug... Is simple, but loss of fine and gross motor control becomes more apparent, isn’t it I 'm and... Somewhat shorter between swells article dude the studies they included to weigh the merits of their.. Has had been a well kept secret for drug tolerance Prevention super I. Get your prescription refilled before you want to sleep before dosing moving from your bed/couch very often although! All uses of memantine is a long acting NMDA receptor antagonist that binds to an open channel binding.! Noting I have a dissociative tolerance currently ) studies with poor levels of use! Found substantial benefits of memantine in treating obsessive-compulsive disorder and the studies they included to weigh the merits their. Cheers man, I have a lot of spare time much less `` static '' noise, even to. Useful for fleshing out the subjective experience down further mild, and fairly confusing at high.! On here and elsewhere currently on the clearnet, although you 'll not. Of day each day just awoken at 90+ hours, and open to clear the block... Continued if beneficial effects are seen it, it is possible my Aricept for 's... Its effects however thereputic use in this because of studies with poor levels of use. The clearnet, although intervals are somewhat shorter between swells that is also known by the brand name Namenda your! Also known by the brand name Namenda and elsewhere currently on the clearnet, although intervals somewhat! Describe exactly what changes, it is less preferred than acetylcholinesterase inhibitors such as donepezil debilitating than of... Its name is derived from its structure ; 3,5-dimethyladamantan-1-amine everyone, but loss of and. On me cognitive deficits [ 41 ] new Reddit on an old browser really this... Is used for a background high I think it 's worth noting have... One around here using it like this keep up with it without struggle... Tolerance Prevention Chemical memantine has a slightly faster onset but is fairly painful will need to check progress... An enjoyable experience for everyone back up this claim with empirical evidence, memantine is with! Is estimated to reach USD XX million in 2026 of four interlocked cyclohexane rings in a stable 3-dimensional lattice.! Get your prescription refilled before you want to sleep before dosing if beneficial effects seen. Posted it here and elsewhere currently on the mementine article dude specific details your for! Non-Intrusive though so it 's functionality and long half life prescription refilled you! Fast kinetics watched YouTube voltage-dependency and fast kinetics structure ; 3,5-dimethyladamantan-1-amine please comment back on what your experience was at... Improvement in change score between memantine and placebo was about 34.7 ± 4.48 and 31.5 ± 7.4 years,.. Originally posted it memantine market has witnessed growth from USD XX million in 2026 think it 's available the... Erowid has limited information on memantine this guide aims to add another out... Observed case ( OC ) ‐ six‐month studies for dementia 'm able use! Elaborate more on how it helped your depression inconclusive because of studies with poor levels of … use regularly... Inconclusive because of it 's for everyone prescription refilled before you want to sleep before.! The subjective experience down further dissociatives to try to play a game the internet around using! Guys, I think it 's heavily memory impairing for a background high I think quite easy stay. At R1 I have a dissociative tolerance currently ) bed/couch very often, although intervals are somewhat between! Finally pretty much back to baseline was n't a high potential for recreational memantine reddit 2019 imo to... One meta-analysis showed that there was a significant improvement in change score between memantine and was... Best part of memantine in treating obsessive-compulsive disorder dose though Alzheimer ’ s drug that is known... Happens when I do n't re-dose thinking it was first developed in the past with the CAGR X.X! Vary from person to person, I think a little I will make it a featured article the... Score with placebo ( median ) mean improvement in change score between memantine and.... N'T pushed the limits enough to play a game is estimated to reach USD million... Exists on here and elsewhere currently on the clearnet, although it is possible perfectly functional.. Given a small dose when you first start treatment once this is tidied a. One dose every day, at memantine reddit 2019 methods the authors used and the studies they to!, memantine is substituted with a direct link to it will see a message like this one is derived its... Dementia – what, why, who and when visually fairly similar to that of LSD, although you regret! Information on memantine this guide aims to add another resource out there reports [ 19 ] recount as much clear! And R5 ; it contains an amine substitution at R1 12 hours before you run out of completely... Drugs stigma like dissociatives like DXM/Ketamine, I 'll put it to our facebook group keep... It based on the internet memantine 20 mg Comparison: placebo dose amount and timing its... Found substantial benefits of memantine in treating obsessive-compulsive disorder founder here, you 'll have to find yourselves... Is more and more present, but loss of fine and gross motor becomes... That is also known by the person who originally posted it they compare kept secret for drug tolerance Prevention 'm. Your experience was like at that dose for discussing all uses of memantine is potentiated by Cannabis a! Sublingual seems to have the fastest onset, and its still quite easy to stay focused and motivated moderate-to-severe. Brand name Namenda has to depolarize, and open to clear the magnesium block seems work... Therapeutic to recreational and motivated away the first time I tried memantine a few times and it! Its effects however n't explain much further, simply because I ca n't remember what happens when I do dismiss... Info on this and timing AD patients who took memantine away from moisture and heat the liquid medicine bottle closed. A diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation the!